Which symptom should be reported when starting selegiline?

• A. Headache is not a concern.
• B. Headache only if accompanied by fever.
• C. Severe headache should be reported to provider.
• D. Headache is expected and nothing to report.

Answer: (C)

Starting selegiline, an MAOI, can raise the risk of a hypertensive episode if interactions occur with certain foods or other medications. A severe headache is a red-flag symptom because it can indicate a dangerous rise in blood pressure that needs medical evaluation. Reporting a severe headache promptly allows a clinician to check blood pressure, review possible drug or dietary interactions, and adjust treatment if needed. Mild headaches may happen, but a severe headache should not be ignored.