Which statement about barbiturates is true?

• A. Barbiturates are contraindicated in pregnancy.
• B. They have no drug interactions.
• C. They do not cause dependence.
• D. They are never overdose.

Answer: (C)

Barbiturates have a safety profile that makes pregnancy a major concern. They cross the placenta and can cause fetal CNS depression, developmental issues, and neonatal withdrawal, so they are generally avoided or considered contraindicated in pregnancy unless there are compelling, tightly monitored reasons. Beyond pregnancy, barbiturates strongly induce liver enzymes, leading to numerous drug interactions and altered levels of other medications. They also carry a high risk of dependence and tolerance, meaning withdrawal and craving can occur with regular use. Overdose is a real and serious risk, often resulting in deep coma and respiratory depression, especially when combined with alcohol or other depressants. Because of these substantial risks, the statement about pregnancy safety is the most accurate overall, while the other points—no interactions, no dependence, and never overdose—do not fit real-world pharmacology.