Which of the following is an adverse reaction of valproic acid?

• A. Hepatotoxicity
• B. Dizziness
• C. GI upset
• D. Pancreatitis

Answer: (D)

Valproic acid can provoke pancreatitis, a recognized and potentially life-threatening adverse reaction. It’s often idiosyncratic and not clearly related to dose. Patients may develop sudden upper abdominal pain that can radiate to the back, with nausea, vomiting, and sometimes fever; lipase or amylase levels rise, and imaging may confirm pancreatitis. Because of the seriousness, the medication is stopped and patients receive supportive care. Dizziness and GI upset can occur with valproate but are common and usually milder, while hepatotoxicity is another important risk that is monitored with liver tests. The key point is that pancreatitis is a distinct, serious adverse effect that requires prompt recognition and discontinuation.