Which of the following is NOT an indication for alprazolam?

• A. Generalized anxiety disorder
• B. Panic disorder
• C. Anxiety associated with depression
• D. Adjunct in the treatment of acute mania and acute psychosis

Answer: (D)

Alprazolam is a benzodiazepine approved mainly for anxiety disorders, especially generalized anxiety disorder and panic disorder, and it can help with anxiety symptoms that occur with depression. It is not indicated for treating acute mania or acute psychosis, which are mood and psychotic disorders that require mood stabilizers and antipsychotics rather than an anxiolytic. While benzodiazepines may be used briefly to help with agitation in some acute settings, they are not appropriate as a primary or adjunctive treatment for mania or psychosis and carry risks like dependence and cognitive impairment if used long-term. So the statement about using alprazolam as an adjunct in the treatment of acute mania and acute psychosis does not align with its approved indications.