Which of the following is a Direct-Acting Skeletal Muscle Relaxant?

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Multiple Choice

Which of the following is a Direct-Acting Skeletal Muscle Relaxant?

Explanation:
Direct-acting skeletal muscle relaxants reduce contraction by acting on the muscle itself rather than slowing the brain. Dantrolene works by blocking the ryanodine receptor in the skeletal muscle's sarcoplasmic reticulum, so calcium cannot be released and the excitation-contraction coupling is dampened directly in the muscle. The other agents are centrally acting: baclofen is a GABA-B agonist in the spinal cord that reduces motor neuron activity, while cyclobenzaprine and chlorzoxazone act on the brainstem/CNS to lower reflexes and overall muscle tone. Therefore, the option that directly targets the muscle to lessen contraction is the direct-acting one.

Direct-acting skeletal muscle relaxants reduce contraction by acting on the muscle itself rather than slowing the brain. Dantrolene works by blocking the ryanodine receptor in the skeletal muscle's sarcoplasmic reticulum, so calcium cannot be released and the excitation-contraction coupling is dampened directly in the muscle. The other agents are centrally acting: baclofen is a GABA-B agonist in the spinal cord that reduces motor neuron activity, while cyclobenzaprine and chlorzoxazone act on the brainstem/CNS to lower reflexes and overall muscle tone. Therefore, the option that directly targets the muscle to lessen contraction is the direct-acting one.

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