Which laboratory parameter should be monitored to assess hepatic function in patients taking valproic acid?

• A. Liver enzymes
• B. Complete blood count
• C. Blood urea nitrogen
• D. Creatinine clearance

Answer: (A)

Valproic acid can cause hepatotoxicity, so the best way to monitor hepatic function is by checking liver enzymes. Measuring aminotransferases like ALT and AST reveals hepatocellular injury, often before symptoms appear. Baseline liver function tests should be obtained before starting therapy and repeated periodically, especially early on when risk is higher. Other options assess blood cell counts or kidney function, not liver injury, so they don’t directly reflect hepatic status in this context.