When administering alprazolam to a client with COPD, which is a concern?

• A. It has no effect
• B. It cures COPD
• C. It improves respiratory function
• D. Alprazolam is a central nervous system (CNS) depressant.

Answer: (D)

The main idea is that alprazolam is a central nervous system depressant. It enhances GABA activity, which calms brain activity but also slows the respiratory center. In a client with COPD, this can blunt the drive to breathe and worsen ventilation, potentially causing hypoventilation, CO2 retention, and reduced oxygenation. It won’t cure COPD or improve lung function, and it does carry a risk of sedation and respiratory compromise—especially at higher doses or when combined with other depressants like alcohol or opioids. So, the concern centers on the potential for respiratory depression in someone already at risk due to COPD.