Valproic acid is contraindicated in which condition?

• A. Pregnancy
• B. Diabetes mellitus
• C. Hypertension
• D. Anemia

Answer: (A)

Valproic acid should not be used during pregnancy because of its high risk of causing birth defects and fetal harm. It is strongly teratogenic, linked to neural tube defects like spina bifida, as well as other congenital malformations and potential long-term neurodevelopmental issues. For this reason, pregnancy is a clear contraindication and alternatives should be considered for seizure control or mood stabilization in pregnant individuals. The other conditions listed—diabetes mellitus, hypertension, and anemia—do not by themselves prohibit valproate use; they may require monitoring, but they do not carry the same fetal risk.