Selegiline is used with levodopa to reduce the dosage needed for symptom control. Adverse effects appear with doses greater than 10 mg. What type of inhibitor is it?

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Multiple Choice

Selegiline is used with levodopa to reduce the dosage needed for symptom control. Adverse effects appear with doses greater than 10 mg. What type of inhibitor is it?

Explanation:
Selegiline works by blocking monoamine oxidase-B in the brain, the enzyme that metabolizes dopamine. By inhibiting MAO-B, it slows the breakdown of dopamine, so levodopa can be more effective at a lower dose for symptom control. The adverse effects appearing at doses above about 10 mg happen because selectivity is lost and MAO-A is inhibited as well, increasing the risk of dietary tyramine interactions and other adverse effects. This mechanism distinguishes it from other options: it isn’t an anticholinergic, it isn’t a dopamine receptor agonist, and it isn’t a COMT inhibitor.

Selegiline works by blocking monoamine oxidase-B in the brain, the enzyme that metabolizes dopamine. By inhibiting MAO-B, it slows the breakdown of dopamine, so levodopa can be more effective at a lower dose for symptom control. The adverse effects appearing at doses above about 10 mg happen because selectivity is lost and MAO-A is inhibited as well, increasing the risk of dietary tyramine interactions and other adverse effects. This mechanism distinguishes it from other options: it isn’t an anticholinergic, it isn’t a dopamine receptor agonist, and it isn’t a COMT inhibitor.

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