Benzodiazepines in pregnancy are contraindicated because they can cause CNS depression in the neonate and respiratory issues. Which outcome is associated with neonatal exposure to benzodiazepines?

• A. Respiratory issues
• B. Hypertension
• C. Hyperactivity
• D. Jaundice

Answer: (A)

Exposure to benzodiazepines during pregnancy can depress the newborn’s brain and breathing because these drugs enhance the inhibitory effects of GABA in the CNS. They cross the placenta and, since the neonate’s metabolism is immature, the drug effects can linger after birth, leading to respiratory depression and reduced muscle tone. This makes respiratory issues the most likely neonatal outcome with in utero exposure.

Hypertension, hyperactivity, and jaundice are not typical direct consequences of neonatal exposure to benzodiazepines.